Extreme mental anguish, when it is as though there is no solution or hope left in the world.

“For those moments which happen to some people when the anguish is so great as to seem to be unbearable. When the mind or body feels as if it had borne to the uttermost limit of its endurance, and that now it must give way. When it seems there is nothing but destruction and annihilation left to face.” – Dr. Edward Bach